Special low‐protein foods ameliorate postprandial off in patients with advanced Parkinson's disease
Identifieur interne : 001742 ( Main/Corpus ); précédent : 001741; suivant : 001743Special low‐protein foods ameliorate postprandial off in patients with advanced Parkinson's disease
Auteurs : Michela Barichella ; Agnieszka Marczewska ; Roberta De Notaris ; Antonella Vairo ; Cinzia Baldo ; Andrea Mauri ; Chiara Savardi ; Gianni PezzoliSource :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
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Abstract
Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 ± 73 min vs. 79 ± 72 min and total off, 164 ± 148 min vs. 271 ± 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21003
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Italy</mods:affiliation></affiliation></author><author><name sortKey="De Notaris, Roberta" sort="De Notaris, Roberta" uniqKey="De Notaris R" first="Roberta" last="De Notaris">Roberta De Notaris</name><affiliation><mods:affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Vairo, Antonella" sort="Vairo, Antonella" uniqKey="Vairo A" first="Antonella" last="Vairo">Antonella Vairo</name><affiliation><mods:affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Baldo, Cinzia" sort="Baldo, Cinzia" uniqKey="Baldo C" first="Cinzia" last="Baldo">Cinzia Baldo</name><affiliation><mods:affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Mauri, Andrea" sort="Mauri, Andrea" uniqKey="Mauri A" first="Andrea" last="Mauri">Andrea Mauri</name><affiliation><mods:affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Savardi, Chiara" sort="Savardi, Chiara" uniqKey="Savardi C" first="Chiara" last="Savardi">Chiara Savardi</name><affiliation><mods:affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation><mods:affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1682">1682</biblScope><biblScope unit="page" to="1687">1687</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3A4A030CF40A1D924B24AF4AA1D6A5391EB6D8A3</idno><idno type="DOI">10.1002/mds.21003</idno><idno type="ArticleID">MDS21003</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>diet</term><term>levodopa</term><term>protein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 ± 73 min vs. 79 ± 72 min and total off, 164 ± 148 min vs. 271 ± 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Michela Barichella MD</name><affiliations><json:string>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</json:string><json:string>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Agnieszka Marczewska MD</name><affiliations><json:string>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Roberta De Notaris ScD, PhD</name><affiliations><json:string>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Antonella Vairo BSc</name><affiliations><json:string>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Cinzia Baldo BSc</name><affiliations><json:string>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Andrea Mauri ScD</name><affiliations><json:string>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Chiara Savardi ScD</name><affiliations><json:string>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Gianni Pezzoli MD</name><affiliations><json:string>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>protein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diet</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>levodopa</value></json:item></subject><articleId><json:string>MDS21003</json:string></articleId><language><json:string>eng</json:string></language><abstract>Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 ± 73 min vs. 79 ± 72 min and total off, 164 ± 148 min vs. 271 ± 174 min, both P > 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, P > 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. 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Istituti Clinici di Perfezionamento, Via Bignami, 1, 20126 Milano, Italy</p></note><affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Agnieszka</forename><surname>Marczewska</surname></persName><roleName type="degree">MD</roleName><affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Roberta</forename><surname>De Notaris</surname></persName><roleName type="degree">ScD, PhD</roleName><affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Antonella</forename><surname>Vairo</surname></persName><roleName type="degree">BSc</roleName><affiliation>Clinical Nutrition Unit, Istituti Clinici di 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For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 ± 73 min vs. 79 ± 72 min and total off, 164 ± 148 min vs. 271 ± 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed. © 2006 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>protein</term></item><item><term>diet</term></item><item><term>Parkinson's disease</term></item><item><term>levodopa</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-12-12">Received</change><change when="2006-03-05">Registration</change><change when="2006-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3A4A030CF40A1D924B24AF4AA1D6A5391EB6D8A3/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial <i>off</i> periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The <i>off</i> phases were significantly shorter after LPP diet than after balanced diet (postprandial <i>off</i>, 49 ± 73 min vs. 79 ± 72 min and total <i>off</i>, 164 ± 148 min vs. 271 ± 174 min, both <i>P</i> < 0.0001). Moreover, a reduction in total <i>off</i> time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, <i>P</i> < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. Consumption of LPP in the first part of the day ameliorates <i>off</i> periods in PD patients, but additional studies including pharmacokinetics are needed. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Special low‐protein foods ameliorate postprandial off in patients with advanced Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Low‐Protein Foods Improve off in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Special low‐protein foods ameliorate postprandial</title></titleInfo><name type="personal"><namePart type="given">Michela</namePart><namePart type="family">Barichella</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><description>Correspondence: Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Via Bignami, 1, 20126 Milano, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Agnieszka</namePart><namePart type="family">Marczewska</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberta</namePart><namePart type="family">De Notaris</namePart><namePart type="termsOfAddress">ScD, PhD</namePart><affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonella</namePart><namePart type="family">Vairo</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cinzia</namePart><namePart type="family">Baldo</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrea</namePart><namePart type="family">Mauri</namePart><namePart type="termsOfAddress">ScD</namePart><affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chiara</namePart><namePart type="family">Savardi</namePart><namePart type="termsOfAddress">ScD</namePart><affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gianni</namePart><namePart type="family">Pezzoli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson Institute ‐ Milan, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2006-10</dateIssued><dateCaptured encoding="w3cdtf">2005-12-12</dateCaptured><dateValid encoding="w3cdtf">2006-03-05</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent><extent unit="references">17</extent><extent unit="words">3679</extent></physicalDescription><abstract lang="en">Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 ± 73 min vs. 79 ± 72 min and total off, 164 ± 148 min vs. 271 ± 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed. © 2006 Movement Disorder Society</abstract><note type="funding">Fondazione Grigioni per il morbo di Parkinson</note><subject lang="en"><genre>Keywords</genre><topic>protein</topic><topic>diet</topic><topic>Parkinson's disease</topic><topic>levodopa</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1682</start><end>1687</end><total>6</total></extent></part></relatedItem><identifier type="istex">3A4A030CF40A1D924B24AF4AA1D6A5391EB6D8A3</identifier><identifier type="DOI">10.1002/mds.21003</identifier><identifier type="ArticleID">MDS21003</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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